| Brent A. French | | Associate Professor, Biomedical Engineering | | Associate Professor of Research, Radiology, SOM | | Ph.D., Louisiana State University | | | | Dr. French has served on faculty at the University of Virginia since 1998. He has published over 30 research articles and has contributed invited reviews and book chapters on various aspects of gene therapy for cardiovascular disease. His original research articles have earned over 1,000 citations as recorded by the Institute for Scientific Information. Dr. French is a fellow of the American Heart Association. He previously held faculty positions at the Baylor College of Medicine and the University of Louisville in Kentucky. | | | | Research Interests | | Work in Dr. French’s laboratory focuses on developing and assessing novel therapies for the treatment and prevention of coronary heart disease. Recent experiments show that potent antioxidants can protect the heart against ischemia/reperfusion injury, perhaps by dampening the inflammatory response that accompanies reperfusion. Thus one project seeks to determine whether gene therapy with antioxidant enzymes can protect the heart against myocardial infarction. A second major research thrust in the laboratory is to elucidate the role of inflammation in the cardiac dysfunction that results from myocardial infarction. The application of cardiac magnetic resonance imaging provides for the serial, non-invasive assessment of cardiac function – which enables Dr. French’s lab to assess the cardioprotective potential of novel anti-inflammatory agents against both myocardial infarction and heart failure. | | |
Sponsored Research
Gene Therapy for Myocardial Stunning and Infarction (funded by: NIH, NHLBI; 1 R01 HL58582-05)
Adenosine Receptor in Remote LV Dysfunction Post-MI (funded by: NIH, NHLBI; 1 R01 HL69494-01)
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