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U.Va. Engineer
Spring 2008, Volume 20, No. 2 Crossing Disciplines to Invent New Technologies By Charlie Feigenoff
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Michael Reed’s own career supports
his contention that the engineering
curriculum, with its emphasis on analytic
thinking and problem-solving, is the
ideal preparation for people interested
in pursuing ideas wherever they lead.
Reed, a professor in the Charles L.
Brown Department of Electrical and
Computer Engineering, is a founder
of Setagon, a company developing an
improved stent to keep open the clogged
arteries of patients with heart disease.
The technology Reed developed with
senior scientist Whye-Kei Lye required
them to range far afield from electrical
engineering, applying knowledge
from materials science, mechanical
engineering and cardiology, as well as
microfabrication technology.
This ability to cross disciplinary
boundaries promises a payoff.
Setagon — with the intellectual property
that Reed and Lye created — has
recently been acquired by one of the
largest medical-device companies in the
world. It saw in Setagon’s technology
a potential solution for a number of
problems associated with the current
generation of stents. Stents today are
coated with a polymer that releases a
drug to prevent scarring of the blood
vessel wall after angioplasty. Applying
the polymer to the stent precisely
has proven difficult, however, and
the polymer has itself been implicated
in scarring.
Reed and Lye, along with Gary
Owens, the director of the University’s
Cardiovascular Research Center, have
developed a nanoporous metallic coating
using a process that Reed encountered
while working with Materials Science
and Engineering Professor Robert
Kelly. This coating can be made of the
same material as the stent itself, making
it easier to apply and potentially more
effective in reducing scarring.
“Nanoporous metals make an ideal
delivery system for drugs,” Reed says.
“They act like a sponge, with very fine
pores that are a thousand times smaller
than the diameter of a human hair.”
Results from preclinical trials have so far
been promising.
The patented technology that
Reed, Lye, Owens and their colleagues
have licensed is representative of the
dozens of technologies developed by
Engineering School professors that have
been licensed by start-ups and moreestablished
companies. They include
ultrasonic medical imaging systems,
using intellectual property patented by
biomedical engineers William Walker
and John Hossack and electrical engineer
Travis Blalock; passive remote sensors
for chemical weapons, created by
mechanical engineer Gabriel Laufer;
and new methods to increase the
efficiency of photovoltaic cells, created
by electrical engineers Mool Gupta and
Barada Nayak.
The point of departure for all these
innovations is, as Reed points out, “the
engineers’ ability to learn things outside
their field.”
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