Past REU Participants & Project Pages

2006 REU Porjects
2006 REU Projects
2006 Participant: Adedayo Adeniran
Project Title: Osteogenesis Using Sintered Microsphere Scaffolds Fabricated
from the Biodegradable Polymer Poly(lactide-co-glycolide)


Faculty Advisor:Michelle Kofron, M.S.; Cato Laurencin, M.D., Ph.D.
Introduction:
Tissue engineering is the application of biological, chemical, and engineering principles toward the repair, restoration, or regeneration of living tissues using biomaterials, cells, and factors alone or in combination.1 The field of tissue engineering provides the opportunity to study and advance the area of regenerative medicine. As the production of tissue engineered constructs to promote repair and regeneration of tissue increases, the need for repairing larger defects still poses a problem. In the area of osteogenesis, this is a concern because of the increased risks involved with the current treatments of autografts and allografts. Autografts do not always provide the quantity of tissue needed, can lead to infection and may leave the patient with pain at the donor site. Allografts can lead to disease transmission and can be rejected by the body because it is foreign. Of the 6 million fractures occurring every year in the United States there are 5 10% which require further, extensive treatment of compromised healing because of either interposition of soft tissue, improper fracture fixation, loss of bone, metabolic disturbances, impairment of blood supply and infection.2 With this number of defects that do not spontaneously repair, there remains a need to employ another method to regenerate bone less invasively. Fabrication of a sintered biodegradable scaffold from poly(lactide-co-glycolide) will be desired to alleviate the necessity to use autografts and allografts for repairing bone defects.
Conclusion:
The study demonstrated that it is feasible to fabricate a microsphere sintered scaffold with the biodegradable poly(lactide-co-glycolide). The biodegradable scaffold does support osteogenesis, as seen in the post-operation x-rays at 4 weeks for the 85:15 PLAGA (Figure 8) and the 80:20 PLAGA (Figure 9) tubular scaffolds. The future of osteogenetic research is promising and with these findings proves to be an ever-developing field.
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